GHK-Cu + AHK-Cu Bundle
Nur für In-vitro-Laborforschung. Nicht für den menschlichen Verzehr, veterinärmedizinische, diagnostische oder klinische Anwendung bestimmt.
Description
This bundle brings together 1× GHK-Cu 50 mg + 1× AHK-Cu 100 mg in a single research bundle, priced around 15% below buying each vial separately. Each peptide is supplied in its own individual vial, so reconstitution and handling stay fully independent per compound.
Every vial is lyophilized research-grade powder at ≥ 99% HPLC purity, with a Certificate of Analysis available on request.
For laboratory research use only. Not for human or veterinary use.
GHK-Cu 50 mg
GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. It is classified as a bioactive tripeptide-copper complex widely studied for its role in tissue remodeling and cellular signaling research.
In biological systems, GHK binds copper ions to form the bioactive GHK-Cu complex, which functions as a signaling molecule involved in maintaining tissue integrity. The peptide influences extracellular matrix remodeling by stimulating collagen synthesis and modulating matrix metalloproteinase activity. It also engages TGF-beta signaling pathways and supports endothelial-related cellular responses. At the genomic level, GHK-Cu has been shown to influence gene expression patterns associated with aging and cellular renewal.
Research interest in GHK-Cu focuses on its ability to influence extracellular matrix remodeling, stimulate collagen synthesis, modulate inflammatory signaling, and support [cellular renewal processes](/product/pinealon-20-mg). Investigations have documented its capacity to reset gene expression patterns associated with aging, activating protective and cellular-pathway genes ([Pickart & Margolina, 2018, International Journal of Molecular Sciences](https://pubmed.ncbi.nlm.nih.gov/29986520/)). Due to its broad biological activity, GHK-Cu is frequently investigated in cellular-pathway biology, skin physiology, and age-related tissue degeneration models. It remains a foundational compound in connective tissue and aging research. See also: Epitalon, Snap-8, MOTS-c 10 mg
AHK-Cu 100 mg
AHK-Cu is a synthetic copper-binding tripeptide composed of alanine, histidine, and lysine. It is classified as a tripeptide-copper complex structurally related to GHK-Cu, differing in the substitution of alanine for glycine at the N-terminus. AHK-Cu is investigated in cosmetic peptide research and hair follicle research models.
In biological systems, AHK binds copper ions to form the bioactive AHK-Cu complex, which functions as a signaling molecule in cellular research models. The peptide engages copper-dependent enzymatic processes, supports endothelial-related cellular responses, and has been studied for its influence on dermal papilla cell signaling pathways. The compact tripeptide-copper structure positions AHK-Cu as a useful comparative research compound alongside other copper-binding peptides.
Research interest in AHK-Cu focuses on hair follicle research, dermal papilla cell models, VEGF and angiogenic-pathway signaling research, and copper-dependent cellular signaling. Comparative research with [GHK-Cu](/product/ghk-cu) explores how the N-terminal residue substitution influences copper-peptide signaling profiles in cellular-pathway research and cosmetic peptide research contexts. See also: GHK-Cu, Snap-8, Pinealon 20 mg
Scientific Background
GHK-Cu + AHK-Cu Bundle combines 2 research compounds: GHK-Cu 50 mg, AHK-Cu 100 mg. Scientific background for each component is documented below.
GHK-Cu 50 mg
GHK was first identified in human plasma and later recognized for its strong affinity for copper ions. The GHK-Cu complex naturally occurs in tissues and fluids, where it participates in signaling pathways related to cellular-response research. Levels of GHK decline with age, which has led to scientific interest in its role in age-related loss of tissue cellular-pathway capacity.
Experimental studies have demonstrated that GHK-Cu can influence the expression of a wide range of genes involved in cell growth, antioxidant defense, inflammatory signaling control, and extracellular matrix organization. These properties have positioned GHK-Cu as an important research compound in studies of cellular-process signaling, skin aging, and connective tissue biology.
AHK-Cu 100 mg
AHK is a tripeptide composed of alanine, histidine, and lysine. The AHK-Cu complex forms when AHK binds a copper ion, creating a bioactive copper-peptide signaling molecule that has been studied alongside the more extensively characterized GHK-Cu tripeptide. The two compounds share the histidine-lysine C-terminal motif required for copper coordination, but differ at the N-terminus, where AHK substitutes alanine for the glycine residue found in GHK.
Experimental studies have investigated AHK-Cu in dermal papilla cell research models, where it has been examined for its influence on growth-related signaling and VEGF-pathway expression. AHK-Cu is also investigated for copper transport, antioxidant defense pathway research, and cellular-pathway signaling within cosmetic and dermatological research contexts.
The structural similarity to GHK-Cu and the substitution of alanine for glycine at the N-terminus has positioned AHK-Cu as a useful comparative research compound for laboratory studies of copper-peptide pharmacology, hair follicle research, and follicle-pathway research.
Structure
GHK-Cu + AHK-Cu Bundle is supplied as a homogeneous lyophilized mixture. Structural details for each compound:
GHK-Cu 50 mg
AHK-Cu 100 mg
Mechanism of Action
Each compound in GHK-Cu + AHK-Cu Bundle engages distinct biochemical targets. Mechanism of action per compound:
GHK-Cu 50 mg
1. Copper Transport and Delivery
GHK binds copper ions and facilitates their safe transport and delivery to cells, supporting copper-dependent enzymatic processes essential for cellular-process research and antioxidant defense.
2. Extracellular Matrix Regulation
GHK-Cu has been shown to stimulate collagen, elastin, and proteoglycan synthesis while simultaneously regulating matrix metalloproteinases, contributing to balanced tissue remodeling.
3. Modulation of Inflammatory Signaling
Research indicates that GHK-Cu may help regulate inflammatory pathways by reducing pro-inflammatory cytokine activity and supporting inflammatory-pathway gene expression profiles.
4. Gene Expression and Cellular Renewal
GHK-Cu influences the expression of genes associated with cell survival, differentiation, and cellular signaling research, supporting cellular turnover and tissue maintenance.
Research Applications
Conclusion
GHK-Cu is a copper-binding tripeptide investigated for its role in cellular-process research, extracellular matrix regulation, and gene expression associated with cellular-response signaling. By supporting copper-dependent biological processes, modulating inflammatory signaling, and promoting structural protein synthesis, GHK-Cu represents a foundational research compound in cellular-pathway biology and aging-related tissue studies.
AHK-Cu 100 mg
1. Copper Transport and Delivery
AHK binds copper ions and facilitates their safe transport and delivery to cellular research models, supporting copper-dependent enzymatic processes essential for cellular-process research and antioxidant defense research.
2. Dermal Papilla Cell Signaling Research
AHK-Cu has been investigated in hair follicle research models, particularly dermal papilla cell cultures, where it is studied for its role in growth-related signaling and cellular activity in follicle-pathway research.
3. VEGF and Vascular Pathway Research
Research has examined AHK-Cu for its association with VEGF (vascular endothelial growth factor) expression and angiogenic-pathway signaling in cellular models, which is relevant to follicle research and dermal cellular-pathway research contexts.
4. Comparative Copper-Peptide Research
AHK-Cu is frequently studied alongside GHK-Cu as a comparative copper-peptide research compound, allowing investigation of how N-terminal residue substitution (alanine versus glycine) influences copper-peptide signaling profiles in cellular research models.
Research Applications
Conclusion
AHK-Cu is a copper-binding tripeptide investigated for its role in hair follicle research, copper transport, and comparative copper-peptide pharmacology research. Its structural similarity to GHK-Cu and substitution of alanine for glycine at the N-terminus makes AHK-Cu a useful research compound for laboratory studies of copper-peptide signaling and follicle-related research models.
References
Published references for each compound in GHK-Cu + AHK-Cu Bundle, listed by component:
GHK-Cu 50 mg
AHK-Cu 100 mg
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