Abaloparatide is a synthetic peptide built from 34 amino acids, designed to mirror the active front portion of parathyroid hormone-related protein (PTHrP 1-34). It is best known in research for studying the PTH1R receptor, and what sets it apart is how it is engineered to favor one particular active state of that receptor.
It has a solid research base as a reference compound for PTH-family analog work, with published studies looking at how it engages the receptor (Hattersley et al., 2016, Endocrinology). That is why labs reach for it when comparing engineered PTHrP variants.
Research Applications
•PTH1R receptor pharmacology research
•Bone-tissue research models
•Structure-activity studies
•PTHrP analog comparison work
Supplied as a lyophilized powder for stability.