Adipotide (FTPP)

Adipotide FTPP peptide is a synthetic vascular-targeting peptidomimetic composed of the cyclic white-fat homing motif CKGGRAKDC linked through a glycine-glycine spacer to the proapoptotic sequence D(KLAKLAK)2. It is studied for its selective interaction with molecular targets associated with white adipose tissue vasculature, making it a notable research compound in experimental models focused on adipose tissue biology, vascular targeting, and metabolic regulation.

Research interest in Adipotide FTPP peptide centers on its ability to induce targeted apoptosis in blood vessels supplying white adipose tissue in preclinical systems. Rather than acting as a conventional metabolic agonist, Adipotide is investigated for ligand-directed vascular disruption within adipose tissue, allowing researchers to study how selective vascular ablation may influence fat mass, tissue remodeling, and downstream metabolic readouts. Foundational work in animal models established this mechanism-based research interest and helped define adipotide as a prototype compound in vascular-targeted obesity research (Kolonin et al., 2004 — Nature Medicine).

(Kolonin et al., 2004 — Nature Medicine).

Current research applications for Adipotide FTPP peptide include white adipose tissue targeting studies, endothelial apoptosis models, adipose vasculature mapping, and investigations into the relationship between vascular remodeling and metabolic function. Follow-up preclinical work in nonhuman primates further expanded scientific interest in adipotide by evaluating its effects in translational obesity models and examining how targeted white-fat vascular disruption may affect body composition and insulin-related outcomes (Barnhart et al., 2011 — Science Translational Medicine).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. COA included with every order. See also: Semaglutide, Tirzepatide, Retatrutide