BAM15 + SLU-PP-332 (Blend)

BAM15 SLU-PP-332 blend is a dual-compound research formulation combining two mitochondrial and metabolic pathway modulators for experimental studies focused on energy regulation, mitochondrial signaling, and transcriptional control of metabolism. This BAM15 SLU-PP-332 blend supports investigation into how distinct bioactive compounds interact within complex regulatory networks involved in cellular energy handling and systemic metabolic signaling.

BAM15 is a mitochondria-targeted protonophore that acts as a selective mitochondrial uncoupler, dissipating the proton gradient across the inner mitochondrial membrane without affecting plasma membrane potential. Preclinical research has explored its role in reducing oxidative stress and modulating energy expenditure without cytotoxic effects observed with earlier uncoupling agents (Coskun et al., 2020 — Nature Communications).

(Kenwood et al., 2014 — Nature Chemical Biology).

SLU-PP-332 is a synthetic agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ), transcription factors that regulate mitochondrial biogenesis and oxidative metabolism. Research has highlighted its potential to enhance mitochondrial gene expression and fatty-acid oxidation capacity in metabolic tissue models (Zuercher et al., 2023 — Journal of Medicinal Chemistry).

Rather than targeting a single pathway, this blend allows researchers to explore complementary mechanisms related to mitochondrial activity, transcriptional regulation of metabolism-related genes, and integrated signaling between peripheral tissues and central regulatory systems.

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.