NAD⁺

NAD⁺ (Nicotinamide Adenine Dinucleotide) is an essential intracellular coenzyme present in all living cells. It is fundamental to cellular energy production, redox balance, and genomic maintenance. As a central regulator of metabolic and signaling pathways, NAD⁺ supports mitochondrial function, DNA repair processes, and cellular resilience under stress.

NAD⁺ functions as a key electron carrier in metabolic reactions, enabling efficient ATP generation. Beyond energy metabolism, it serves as a required substrate for enzymes involved in cellular repair, epigenetic regulation, and stress adaptation. Declining NAD⁺ levels have been associated with aging and metabolic dysfunction, making it a core molecule of interest in longevity, metabolic, and neurobiological research.

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.

NAD+ peptide (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every living cell, serving as a central mediator of cellular energy metabolism, redox reactions, and enzymatic signaling. As a substrate for key enzyme families including sirtuins (SIRT1–SIRT7), poly(ADP-ribose) polymerases (PARPs), and CD38, the NAD+ peptide plays an essential role in processes ranging from mitochondrial function to genomic stability and epigenetic regulation.

The biological significance of NAD+ centers on its dual function as an electron carrier in metabolic pathways and a consumable substrate for signaling enzymes. In oxidative metabolism, NAD+ accepts electrons during glycolysis, the citric acid cycle, and fatty acid oxidation, facilitating ATP production through the mitochondrial electron transport chain. Beyond energy metabolism, NAD+ peptide serves as the obligate co-substrate for sirtuins, a family of NAD+-dependent deacetylases that regulate gene expression, DNA repair, mitochondrial biogenesis, and inflammatory responses. PARP enzymes similarly consume NAD+ during DNA damage repair, linking cellular NAD+ availability directly to genomic integrity and stress resilience.

Research into NAD+ peptide spans several active and rapidly expanding domains, including age-related decline in cellular NAD+ levels and its consequences for mitochondrial function, sirtuin-mediated regulation of metabolism and longevity pathways, DNA repair capacity and PARP activation under genotoxic stress, neurodegeneration and neuroprotective mechanisms linked to NAD+ bioavailability, and cardiovascular function and endothelial health. Landmark studies have established that NAD+ levels decline progressively with age across multiple tissues, contributing to metabolic dysfunction and increased disease susceptibility (Verdin, 2015 – Cell Metabolism). Supplementation strategies aimed at restoring NAD+ pools have shown promising results in preclinical models of aging and neurodegeneration (Zhang et al., 2016 – Science).

(Rajman et al., 2018 — Cell Metabolism).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. Store lyophilized NAD+ peptide at -20°C, protected from light and moisture. Reconstituted solution should be kept at 2–8°C and used within 30 days. Avoid repeated freeze-thaw cycles. Certificate of Analysis (COA) included with every order. Explore related research compounds: BPC-157, Epitalon, and MOTS-c.