MOTS-c 10 mg

MOTS-c is a mitochondria-derived peptide consisting of 16 amino acids and encoded directly by mitochondrial DNA. Unlike classical peptides encoded in the nucleus, MOTS-c functions as a signaling molecule linking mitochondrial activity with nuclear gene regulation. It plays a central role in metabolic balance, cellular stress adaptation, and age-associated physiological regulation.

Through activation of AMP-activated protein kinase (AMPK), MOTS-c coordinates multiple metabolic pathways, including glucose utilization, lipid oxidation, and energy expenditure. These effects contribute to improved metabolic flexibility, resistance to insulin dysfunction, and protection against obesity-related disturbances. In addition, MOTS-c demonstrates antioxidant and anti-inflammatory properties, supporting cardiovascular and metabolic health at the cellular level.

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.

MOTS-c is a mitochondria-derived peptide consisting of 16 amino acids and encoded directly by mitochondrial DNA. Unlike classical peptides encoded in the nucleus, MOTS-c functions as a signaling molecule linking mitochondrial activity with nuclear gene regulation. It plays a central role in metabolic balance, cellular stress adaptation, and age-associated physiological regulation.

Through activation of AMP-activated protein kinase (AMPK) via the AICAR pathway, the MOTS-c peptide coordinates multiple metabolic pathways, including glucose utilization, lipid oxidation, and energy expenditure. Under conditions of metabolic stress, MOTS-c translocates from the mitochondria to the nucleus, where it modulates the expression of stress adaptation genes through antioxidant response elements (ARE). These effects contribute to improved metabolic flexibility, resistance to insulin dysfunction, and protection against obesity-related disturbances.

The MOTS-c peptide is actively investigated across several research domains, including insulin sensitivity and glucose homeostasis, age-related functional decline, exercise physiology and skeletal muscle metabolism, bone remodeling and osteoblast differentiation, and inflammatory response modulation. Published studies have demonstrated that MOTS-c administration in animal models can prevent diet-induced obesity and improve metabolic regulation (Lee et al., 2015 – Cell Metabolism). Circulating levels of MOTS-c peptide have been shown to decline with age, while exercise significantly upregulates its expression in skeletal muscle (Reynolds et al., 2021 – Nature Communications).

(Lee et al., 2015 — Cell Metabolism).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. Store at -20°C, protected from light and moisture. Certificate of Analysis (COA) included with every order. Explore related research peptides: BPC-157, TB-500, and Epitalon.