TB500 Fragment (17-13)

TB-500 peptide is a synthetic fragment derived from Thymosin Beta-4, a naturally occurring peptide present in most human cell types. This compound corresponds to the active region at positions 17-23 of the parent molecule, containing the LKKTETQ sequence that is central to its biological function in actin regulation and cellular signaling. Thymosin Beta-4 is a 43-amino acid peptide encoded by the TMSB4X gene, widely expressed across tissues including platelets, macrophages, and epithelial cells.

TB-500 peptide works by binding to G-actin, helping regulate how cells reorganize their internal structure. This process supports cell movement and tissue remodeling. By maintaining a pool of unpolymerized actin monomers, the fragment enables rapid cytoskeletal reorganization when cells receive migration or repair signals. It is also studied for its role in promoting new blood vessel formation through VEGF-related pathways, an area of active interest in regenerative research. Additional studies have explored its interaction with the Arp2/3 complex, which is involved in branched actin network formation.

(Malinda et al., 1999 — FASEB Journal).

Current research on TB-500 peptide covers wound healing and tissue repair, cell migration and cytoskeletal dynamics, blood vessel formation and angiogenesis, musculoskeletal recovery in tendon and ligament models, and inflammatory response modulation. Studies have confirmed that the LKKTETQ fragment retains meaningful activity in wound repair models, promoting re-epithelialization and collagen deposition (Malinda et al., 1999 – FASEB Journal). Ongoing work explores its potential in cardiovascular and neurological research contexts, including a first-in-human Phase I study evaluating safety and pharmacokinetics (Wang et al., 2021 – J Cell Mol Med).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. COA included with every order. See also: BPC-157, MOTS-c, Epitalon