MOTS-c 40 mg

MOTS-c 40 mg peptide is a mitochondria-derived signaling compound consisting of 16 amino acids encoded directly by mitochondrial DNA. Unlike classical peptides encoded in the nucleus, MOTS-c functions as a regulatory molecule linking mitochondrial activity with nuclear gene expression. It plays a central role in metabolic balance, cellular stress adaptation, and age-associated physiological regulation.

Through activation of AMP-activated protein kinase (AMPK), MOTS-c coordinates multiple metabolic pathways including glucose utilization, lipid oxidation, and energy expenditure. These effects contribute to improved metabolic flexibility, resistance to insulin dysfunction, and protection against obesity-related disturbances. Research into this MOTS-c 40 mg peptide has highlighted its role as a mitochondrial-to-nuclear retrograde signaling molecule with broad implications for metabolic homeostasis (Lee et al., 2015 — Cell Metabolism).

(Lee et al., 2015 — Cell Metabolism).

MOTS-c also demonstrates antioxidant and anti-inflammatory properties, supporting cardiovascular and metabolic health at the cellular level. Preclinical studies have further explored its potential relevance to age-related physiological decline, longevity pathways, and mitochondrial bioenergetics (Reynolds et al., 2019 — Nature Communications).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.