Semax 10 mg

Semax peptide is a synthetic heptapeptide derived from the ACTH(4-10) fragment of adrenocorticotropic hormone, originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. With the sequence Met-Glu-His-Phe-Pro-Gly-Pro, the Semax peptide was designed to retain the neurotropic activity of ACTH while eliminating its hormonal effects on the adrenal cortex, making it a focused tool for neuroscience research.

The mechanism of action of Semax peptide involves modulation of several neurotrophic and neuroprotective pathways. Research has shown that the compound influences expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, both of which play central roles in neuronal survival, synaptic plasticity, and memory formation. Additionally, Semax interacts with the melanocortin system and has been observed to modulate serotonergic, dopaminergic, and cholinergic neurotransmitter systems in preclinical models.

Current research on Semax peptide spans several domains, including neurotrophic factor regulation and BDNF expression, neuroprotective mechanisms in ischemic and oxidative stress models, cognitive function and memory-related signaling pathways, neuroinflammatory response modulation, and gene expression profiling in central nervous system tissue. Studies have demonstrated that the ACTH(4-10) fragment and its analogs can upregulate neurotrophic factor expression in rodent brain tissue (Dolotov et al., 2006 – Doklady Biological Sciences), while additional research has explored its effects on immune-related gene expression in cerebral ischemia models (Gusev et al., 2014 – BMC Genomics).

(Dolotov et al., 2006 — Journal of Neurochemistry).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. COA included with every order. See also: BPC-157, NAD+, Epitalon