IGF-1 LR3 1 mg

IGF-1 LR3 is a synthetic 83-amino-acid analog of insulin-like growth factor 1 (IGF-1), engineered with an N-terminal 13-residue extension and an Arg³ substitution. It is classified as an IGF-1-receptor (IGF-1R) research peptide developed for investigation of IGF-1 signaling research in laboratory models.

Through engagement of the IGF-1 receptor while exhibiting markedly reduced affinity for the six IGF-binding proteins (IGFBPs), IGF-1 LR3 is investigated as a tool compound for studying PI3K/Akt signaling research, MAPK/ERK pathway engagement, and extended-bioavailability IGF-1R activation in controlled research models. The reduced IGFBP binding profile makes IGF-1 LR3 a useful research compound where prolonged receptor engagement is methodologically relevant.

IGF-1 LR3 is actively investigated across several research domains, including IGF-1-receptor signaling research, PI3K/Akt pathway investigation, MAPK/ERK signaling research, and cell-culture research models. Published characterization established that LR3 IGF-1 variants display reduced IGFBP binding and approximately 2.5-fold greater anabolic potency compared with native IGF-1 in laboratory animal research models, supporting continued investigation in IGF-1 signaling research (Tomas et al., 1992, Biochemical Journal).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.

Native IGF-1 is a 70-amino-acid polypeptide whose circulating availability is governed by a family of six IGF-binding proteins (IGFBP-1 through IGFBP-6). Because more than 99 percent of circulating IGF-1 in laboratory research models is bound to IGFBPs, the free, receptor-engageable fraction is limited, complicating receptor-level investigation.

IGF-1 LR3 was developed in the early 1990s as an engineered IGF-1 analog combining two structural modifications: an Arg³ substitution (replacing the native Glu³ in the IGFBP-binding region) and a 13-residue N-terminal extension (MFPAMPLLSLFVN). These modifications produce a 83-amino-acid analog that retains full IGF-1R receptor affinity while exhibiting markedly reduced IGFBP binding, extending receptor-engageable availability in research models.

This positioning at the intersection of IGF-1-receptor pharmacology, IGFBP-binding research, and PI3K/Akt signaling research has made IGF-1 LR3 a peptide of considerable interest in laboratory investigations of IGF-1-pathway dynamics, cellular signaling research, and cell-culture research models.

IGF-1 LR3 Structure

1. IGF-1 Receptor (IGF-1R) Engagement

IGF-1 LR3 binds the type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane receptor tyrosine kinase. Receptor engagement triggers autophosphorylation of intracellular tyrosine residues and recruits IRS-1, IRS-2, and Shc adapter proteins for downstream signaling research.

2. PI3K/Akt Signaling Research

Through IGF-1R engagement, IGF-1 LR3 is investigated as a probe for PI3K/Akt pathway activation, including mTOR-coupled signaling and downstream phosphorylation cascades involved in cellular signaling research, protein-pathway research, and laboratory models of cell-survival signaling.

3. MAPK/ERK Signaling Research

IGF-1 LR3 engages the Ras/Raf/MEK/ERK cascade through IGF-1R-coupled Shc/Grb2/SOS signaling, supporting research into MAPK pathway activation and downstream transcriptional research in cell-culture research models.

4. Reduced IGFBP Binding Profile

The Arg³ substitution and N-terminal extension reduce IGF-1 LR3 affinity for IGFBPs, increasing receptor-engageable availability in research models. This extended bioavailability supports laboratory investigation in research designs where sustained IGF-1R engagement is methodologically required.

Research Applications

Conclusion

IGF-1 LR3 represents a structurally engineered IGF-1 analog research peptide that engages the IGF-1 receptor while exhibiting reduced IGFBP binding. Through PI3K/Akt and MAPK/ERK signaling research applications, it serves as a useful tool compound for examining IGF-1 signaling research, receptor tyrosine kinase pharmacology, and extended-bioavailability receptor engagement in controlled laboratory research models.

Research Use Disclaimer

This product is intended for research and laboratory use only. It is designed exclusively for in vitro research purposes. All information provided is for educational and research reference only. This product is not intended for human or animal use. It is not a drug, food, or cosmetic and must not be marketed, labeled, or used as such. Use and handling are restricted to trained and qualified professionals.