Kisspeptin 10 mg

Kisspeptin peptide is a family of neuropeptides encoded by the KISS1 gene, first identified for their role as endogenous ligands of the GPR54 receptor (now known as KISS1R). The most studied form, Kisspeptin-10, consists of the C-terminal decapeptide fragment that retains full receptor binding and activation capacity. Kisspeptin peptide has become a central focus in reproductive and neuroendocrine research due to its upstream position in the hypothalamic-pituitary-gonadal (HPG) axis.

The primary mechanism of action involves binding to the KISS1R receptor on gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. This activation stimulates GnRH release, which in turn triggers the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. Through this signaling cascade, Kisspeptin peptide acts as a master regulator of reproductive hormone output, integrating metabolic, environmental, and developmental signals into the neuroendocrine control of fertility.

Research on Kisspeptin peptide spans several active domains, including puberty onset and the developmental activation of the HPG axis, fertility regulation and ovulation induction mechanisms, metabolic integration with reproductive function through leptin and insulin signaling, tumor metastasis suppression linked to the original KISS1 gene discovery, and neuroendocrine control of seasonal and circadian reproductive rhythms. Studies have confirmed that kisspeptin administration potently stimulates gonadotropin secretion in multiple species including humans (Dhillo et al., 2005 – Journal of Clinical Endocrinology & Metabolism), while further research continues to explore its role in linking energy balance to reproductive capacity (Castellano et al., 2007 – Endocrinology).

(Oakley et al., 2009 — Endocrine Reviews).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. COA included with every order. See also: BPC-157, PT-141, Melanotan 2