Dermorphin 10 mg

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin of South American tree frogs of the genus Phyllomedusa, particularly Phyllomedusa sauvagei. This peptide is characterized by the unusual presence of a D-alanine residue at position 2, a feature exceedingly rare in vertebrate-derived peptides that confers high resistance to enzymatic degradation and enhanced biological stability.

Research interest in Dermorphin focuses on its role as a highly selective and potent µ-opioid receptor (MOR) agonist in experimental models of nociception, opioid receptor pharmacology, and structure-activity relationship studies. Its unique D-amino acid incorporation and distinct sequence — differing from all known mammalian opioid peptides — make it a valuable tool for investigating opioid receptor binding, signal transduction, and analgesic pathway mechanisms (Montecucchi et al., 1981 — Peptides).

Current research applications include receptor selectivity profiling, pain pathway modulation studies, and comparative opioid pharmacology. Dermorphin's exceptionally high MOR affinity — several times greater than morphine — makes it a reference compound in opioid receptor research. Studies continue to explore its structural basis for receptor selectivity and its utility in mapping opioid signaling cascades across central and peripheral nervous system models (Lazarus et al., 1989 — International Journal of Peptide Research).

The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling. COA included with every order. See also: DSIP, Selank, Semax